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No Brexit
AchievementsStop Britain leaving the EU

No Idea
AchievementsEvolve 'Total Brain Death' in the first year and win

Nocturnal
SymptomsInfected struggle to sleep at night, increasing infectivity.

Non Starter
AchievementsStop DarkWater from analysing the Necroa Virus

Normal Shuffle
AchievementsWin 5 times in a row on normal difficulty with the shuffle strain enabled
Norovirus
PathogensThe Norovirus is a upcoming virus category pathogen for the 2025 update. It focuses on food and water contamination and human contact. It can survive long time outside infected so it is difficult to cure. However, it has a low base lethality so it needs a careful strategy to win.

Norway
CountriesA rich, urban country. Typically has a cold, humid climate.

Not Another Zombie Game
AchievementsWin a game with the Necroa Virus without making a single zombie

Not Just a Pretty Face
AchievementsMake every ape in the world intelligent

Not Necroa
AchievementsDiscover the Zombie Panic Combo

Nox Eternis
MechanicsThe track is ominous, consisting of vampire growls, a church organ, choir, etc.

Nuchal Rigidity
SymptomsMinor muscle spasms prevent flexing of the neck due to increased rigidity of surrounding muscle.
Nuclear Retaliation
EventsNuclear Retaliation is a news event on Plague Inc. The event begins with a news popup informing that the USA president has contracted the plague and has taken ill, and it is unknown if he can remain in power. Shortly after, another popup informs that the president has been replaced by Spalin, instead of the vice president, as it should be.

Nuclear Warfare
AchievementsLaunch a Nuclear Strike in a multiplayer game

Nucleic Acid Neutralisation 1
MechanicsReset lethal potential of weapon. Will take time to regenerate

Nucleic Acid Neutralisation 2
MechanicsReset lethal potential of weapon. Will take time to regenerate

Nucleic Acid Neutralisation 3
MechanicsReset lethal potential of weapon. Will take time to regenerate

Obsession
SymptomsSevere damage to orbital cortex triggers OCD - forcing host to obsess over a specific worm related task

Occipital Mesh
SymptomsTendrils mesh with occipital lobe - the visual processing centre. Hosts less likely to notice worm infections

Oink oink
AchievementsDiscover the Swineflu Combo

Olympic Spoiler
AchievementsHelp the Olympics go viral
Olympics Mystery
EventsThe Olympics mystery is a news event in Plague Inc. It eventually leads to Olympics back on!. If the host country has not been infected yet, or even if it has, there will be another news popup, <plague name> infects <country>!. Drug Resistance I must be acquired for this to work. The achievement Olympic Spoiler may be acquired for infecting the host country in this way.

On the fence
AchievementsTear the world in two with indecision

On The Naughty List
AchievementsPut humanity on Santa's naughty list